ZHUZHOU CENTER BIOLOGY TECHNOLOGY CO.,LTD

Quick Detail:

Product Name:Gliquidone

Synonym:ardf26;ardf26se;benzenesulfonamide,n-((cyclohexylamino)carbonyl)-4-(2-(3,4-dihydro-7-methoxy-4;GLIQUIDONE;GLIQUIDONE 99%;Gliquidone Tablets;Glurenorm

CAS:33342-05-1

MF:C27H33N3O6S

MW:527.63

EINECS:251-463-2

Appearance : White powders

Melting point: 168-173º C

Standard: Enterprise Standard

Usage: Antidiabetic

Description:

Gliquidone is an anti-diabetic drug in the sulfonylurea class. In patients with diabetes mellitus, there is a deficiency or absence of a hormone manufactured by the pancreas called insulin. Insulin is the main hormone responsible for the control of sugar in the blood. Gliquidone is an antidiabetic medication which is used in those patients with adult maturity onset or non-insulin dependent diabetes (NIDDM). It works by lowering blood sugar levels by stimulating the production and release of insulin from the pancreas. It also promotes the movement of sugar from the blood into the cells in the body which need it.

Mechanism of Action:

The mechanism of action of gliquidone in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells, and increasing sensitivity of peripheral tissues to insulin. Gliquidone likely binds to ATP-sensitive potassium channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Membrane depolarization stimulates calcium ion influx through voltage-sensitive calcium channels. This increase in intracellular calcium ion concentration induces the secretion of insulin.

Usage:

1. Hypoglycemic drugs, for the treatment of mild, non insulin dependent diabetes mellitus.

2. Glibenclamide and glibenclamide, glibenclamide, which belongs to the second generation oral sulfonylurea drugs, with the mechanism of toluene sulfonyl Ding Niao, its hypoglycemic effect was the strongest sulfonylurea, intensity for tolbutamide 200 ~ 250 times. Be selective effect on pancreatic beta cells, promote the secretion of insulin, can enhance the hypoglycemic effect of exogenous insulin, insulin receptor after strengthening effect.

3. Glibenclamide is one of the drugs currently used to treat type 2 diabetes, the most often used, because the utility function is fast and strong, so after the application has obvious effect, can effectively control blood sugar, high blood sugar, is applicable to other sulfonylurea hypoglycemic effect not beautiful person.

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